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The Jaw May Be Key To Fixing A Bad Heart

(center) Yi-Gang Wang, MD, PhD, professor in UC's Dept. of Pathology and Laboratory Medicine, is using facial stem cells to regenerate the heart.

As crazy as it may sound to the non-scientist, cells in a patient's jaw may be able to rejuvenate their bad heart.

Yi-Gang Wang, MD, PhD, a professor in the Department of Pathology and Laboratory Medicine and former heart surgeon, explains that when we are growing in the womb our facial muscle cells develop near the heart. They eventually migrate to the head and are similar to heart cells.

In small animals Wang has  taken cells from the animal's facial muscle to the lab, enhanced them and turned them into beating heart cells. Wang says this has translated into regeneration of the heart muscle. He's ramping up research in large animal models. Human trials could begin in five years.

Wang says traditional treatments, including medicine and surgery, cannot cure or recover heart tissue and they come with some dangers, such as reduced oxygen, complications from bypass surgery, the ability of a donor heart and the risk of rejection.

After facial cells are harvested scientists would need about two weeks in a lab before the modified cells would be ready to attach to the heart.

The modified cells would be administered via injection or a patch. Wang says humans could then see heart improvement in about a month.

This story originally aired February 6, 2017

With more than 30 years of journalism experience in the Greater Cincinnati market, Ann Thompson brings a wealth of knowledge and expertise to her reporting. She has reported for WKRC, WCKY, WHIO-TV, Metro Networks and CBS/ABC Radio. Her work has been recognized by the Associated Press and the Society of Professional Journalists. In 2019 and 2011 A-P named her “Best Reporter” for large market radio in Ohio. She has won awards from the Association of Women in Communications and the Alliance for Women in Media. Ann reports regularly on science and technology in Focus on Technology.