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Donna Skoda is retiring at the end of the year. She led the department through major health crises including the opioid epidemic and COVID-19.

A diplomatic row has frozen U.S.-Mexican efforts to target drug cartels. American officials say illicit fentanyl from labs in Mexico is driving a surge in overdose deaths.

Some observers are wondering why American Crossroads, the Karl Rove-inspired superPAC, would bother to run a political attack ad against Hollywood star Ashley Judd, an outspoken supporter of President Obama who has said she's mulling a 2014 run against Republican Sen. Mitch McConnell of Kentucky.

History books tell us that times were hard in the 1800s. But there was occasional humor. Some of it was even funny.

The contest between Democrat Jon Ossoff and Republican Karen Handel has obliterated spending records. A win for the Democrats would be a blow to President Trump, but the race remains incredibly close.

Vice President Harris is delivering what her campaign describes as her "closing argument" Tuesday night. She's speaking from the same spot her opponent spoke on Jan. 6, 2021.

For 30 years, trumpet and flugelhorn player Diego Urcola has toured and recorded with Cuba-born saxophonist Paquito D'Rivera. For his own new album, Urcola hired his boss as featured sideman.

The pandemic state of emergency was lifted but there are still plenty of viruses to worry about. Here are some highlights of our viral coverage this year, including NPR's "Hidden Viruses" series.

NPR's Rachel Martin talks to Ukrainian politician Volodymyr Omelyan, who left his job and family, and has been fighting against the Russians on the frontlines for the last six months.

The recent stock market plunge has many wondering whether the U.S economy is taking a turn for the worse. Steve Inskeep speaks with Austan Goolsbee, top White House economist under President Obama.